Transdermal medical delivery and release systems have been on the market since 1982, after more than 20 years of extensive market research and ***** major pharmaceutical companies now market Transdermel Systems, for dispensing a great variety of solid and liquid medical egents and others solutions, including the now widely recongnized anti-smoking Nicotine, clonodine, nitroglycere and estradiol, whith many more about to hit the market ***** has evolved to a flexible System of multy-layered polymeric laminates and reservoir system which stores and release active ingrdients under stric rate control, which can provide zero-order constant release for lfe of the ***** life can be programmed to range from 1 hour to several ***** technology eliminates any possibility of dosage dumping.