Neohesperidin are a natural new nutrition sweetener widely existing in plants of dry orange peel, can be derived from extraction. Since the sweetness are 1300-1500 times than sugar, Neohesperidin are widely used in fruit juice, wine, beverage, bakery and pharmaceutical formulations sweeteners (Jiao deodorant), and particularly suitable for diabetic patients as food. In addition, it also can cure capillary fragility and protein permeability excessive. It is referred to as the maintenance of capillary permeability of vitamin or vitamin P,can be used as hypertension and myocardial infarction drugs. As pharmaceutical raw materials in pharmaceutical industry, it is the main components of Chinese patent medicines Naomaitong.